Exciting Breakthrough Gene Therapies May Help People Enjoy Longer, Healthier Lives

Written by Dr. Jonathan Peterson, Updated on January 24th, 2024, Published on February 17th, 2021

Reading Time: 2 minutes

Geriatric Medicine, Genetics, and Endocrinology are tightly wound disciplines at the forefront of advancing medical science and technology. One of the long-term goals of these disciplines is Anti-Aging. As we learn more about the processes that induce aging, we can develop strategies to overcome those processes, thus increasing the quality of life and length of life at the same time.

Aging is a complex set of circumstances that we're just beginning to really understand, but we do know that it occurs all the way down to a cellular level. Cellular Senescence is a term that describes the end-of-life stage of a cell where its growth permanently ceases.

This physiological end-point is determined by a combination of inherited factors. Some of these factors are genetically baked in from birth. Others are activated by lifestyle, circumstance, or other environmental causes. The scientific field that studies how these on-off switches are flipped is known as Epigenetics.

Few Studies Explore Epigenetic Treatments to Slow Down Aging

While we do understand a handful of these genes and have hypotheses regarding how they impact aging, there is still a tremendous amount of information left to be revealed. In spite of this growing knowledge, there is minimal research going into the development of treatments that can help promote longevity and health via epigenetic intervention.

Most current research involving epigenetic life-extension is conducted in animal laboratories. A collaboration of Chinese medical research facilities recently released data from a recent study designed to gather information regarding how animals and humans regulate aging at the cellular level.

Part of this research involves the Beijing Institute of Genomics, which is hunting for genes that encourage cellular senescence in humans. The institute is exploring the human genome with CRISPR/Cas9. By finding these genes, we can study them further to identify new potential therapies to overcome health issues related to aging.

Utilizing stem cells that experienced premature aging, they found 100+ genes that appeared to relate to senescence. They narrowed that list down to a hypothesized top 50 genes most likely to affect aging, then flipped the genetic switch using targeted sgRNAs.

KAT7 Overactivity Detrimental to Cellular Rejuvenation

One of the most notable of those 50 genes was KAT7. Lower KAT7 activity was correlated with controlled cellular senescence, but excessive activity inhibited cellular development. By inactivating KAT7, stem cells experienced rejuvenation, relieving them of their stasis.

The body of research thus far has shown that inflammation and senescence of organ/tissue cells lead to an increased incidence of age-related conditions and perceived aging. In animal research, the removal of senescent cells helps prevent the degeneration of tissues and has a positive impact on the lifespan of good health.

This new study provides evidence that the injection of serum to mitigate KAT7 activity improved the inflammatory profile in older mice and led to lower levels of cellular senescence in the liver.

Based on these results, inhibiting the activity of a single problematic gene may be enough to improve health and extend the lifespan, at least in mice. When this same intervention was applied to stem cells, it led to relatable results.

This study adds another prominent member to the list of genes that inhibit cellular rejuvenation and also provides the groundwork for taking advantage of the use of genetic manipulation to help humans live longer and healthier lives.

Reference: "A genome-wide CRISPR-base screen identifies KAT7 as a driver of cellular senescence" was published online in Science Translational Medicine on Jan. 6, 2021.

Contact Us For HGH And Sermorelin Injection Treatment

Name (*)
Email (*)
Phone (*)
Select A Program (*)
Select US State (*)
Select Age (30+ only)

androgel testosterone consultants gel pump 639214936

Related Posts
procedure of blood capture from vein from male in hospital
height hgh chart growth.webp
hgh chart human growth.webp

List of USA state clinics - click a flag below for blood testing clinics.

alabama clinics
Alabama Hormone Blood Analysis
alaska clinics
Alaska Hormone Blood Analysis
arizona clinics
Arizona Hormone Blood Analysis
arkansas clinics
Arkansas Hormone Blood Analysis
california clinics
California Hormone Blood Analysis
colorado clinics
Colorado Hormone Blood Analysis
connecticut clinics
Connecticut Hormone Blood Analysis
delaware clinics
Delaware Hormone Blood Analysis
florida clinics
Florida Hormone Blood Analysis
georgia clinics
Georgia Hormone Blood Analysis
hawaii clinics
Hawaii Hormone Blood Analysis
idaho clinics
Idaho Hormone Blood Analysis
illinois clinics
Illinois Hormone Blood Analysis
indiana clinics
Indiana Hormone Blood Analysis
iowa clinics
Iowa Hormone Blood Analysis
kansas clinics
Kansas Hormone Blood Analysis
kentucky clinics
Kentucky Hormone Blood Analysis
louisiana clinics
Louisiana Hormone Blood Analysis
maine clinics
Maine Hormone Blood Analysis
maryland clinics
Maryland Hormone Blood Analysis
massachusetts clinics
Massachusetts Hormone Blood Analysis
michigan clinics
Michigan Hormone Blood Analysis
minnesota clinics
Minnesota Hormone Blood Analysis
mississippi clinics
Mississippi Hormone Blood Analysis
missouri clinics
Missouri Hormone Blood Analysis
montana clinics
Montana Hormone Blood Analysis
nebraska clinics
Nebraska Hormone Blood Analysis
nevada clinics
Nevada Hormone Blood Analysis
new hampshire clinics
New Hampshire Hormone Blood Analysis
new jersey clinics
New Jersey Hormone Blood Analysis
new mexico clinics
New Mexico Hormone Blood Analysis
new york clinics
New York Hormone Blood Analysis
north carolina clinics
North Carolina Hormone Blood Analysis
ohio clinics
Ohio Hormone Blood Analysis
oklahoma clinics
Oklahoma Hormone Blood Analysis
oregon clinics
Oregon Hormone Blood Analysis
pennsylvania clinics
Pennsylvania Hormone Blood Analysis
rhode island clinics
Rhode Island Hormone Blood Analysis
south carolina clinics
South Carolina Hormone Blood Analysis
south dakota clinics
South Dakota Hormone Blood Analysis
tennessee clinics
Tennessee Hormone Blood Analysis
texas clinics
Texas Hormone Blood Analysis
utah clinics
Utah Hormone Blood Analysis
vermont clinics
Vermont Hormone Blood Analysis
virginia clinics
Virginia Hormone Blood Analysis
washington clinics
Washington Hormone Blood Analysis
washington d.c clinics
Washington, D.C. Hormone Blood Analysis
west virginia clinics
West Virginia Hormone Blood Analysis
wisconsin clinics
Wisconsin Hormone Blood Analysis
wyoming clinics
Wyoming Hormone Blood Analysis

How useful was this post?

Click on a thumb to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this post.

Word Count: 590