The Results Are In: The Effects of TRT on Men with Prostate Cancer

Written by Dr. Jonathan Peterson, Updated on May 12th, 2024, Published on February 25th, 2021

Reading Time: 4 minutes

For decades, the suspicion that testosterone replacement therapy (TRT) causes prostate cancer in men who elect to undergo therapy has caused doctors to be incredibly cautious when prescribing therapy or deciding not to even offer it at all.

Truthfully, it is better to be on the safe side and thankfully there are doctors who want to make sure we are not putting ourselves at risk with potentially harmful therapy methods.

Some men might truly need TRT, however, especially if the deficiency has reached a point where severe depression has set in – a debilitating side effect of low testosterone or hypogonadism.

And the potential risk of developing prostate cancer may not outweigh the benefits of even temporary TRT. Let's look at the results of 21 clinical trials studying the effects of TRT on prostate cancer and see for ourselves!

The idea that TRT causes prostate cancer has been around since the 1950s. It all began with an anecdotal study of only one subject who was castrated and later underwent TRT, developing prostate cancer.

When a man is castrated, his prostate shrinks and atrophies. Once TRT is introduced, this causes the prostate tissue to grow again, potentially becoming a target for cancer cells. However, this is all speculation and when TRT is used by men with normal prostates, the studies have found that testosterone may actually protect the prostate!

It appears that men with higher testosterone levels demonstrate a lower risk of developing prostate cancer and TRT does not increase the risk of prostate cancer.

TRT Has Neutral Effects on Prostate Cancer in Patients

Because of the ongoing debate between doctors and researchers regarding the safety of TRT in regards to prostate cancer in men, Dr. Mehdi Kardoust Parizi, MD, decided to get a group of his colleagues together to perform an extensive literature review on the topic.

Dr. Parizi is an Assistant Professor of Urology at Tehran University of Medical Sciences. They studied the data compiled from a total of 21 clinical studies.

Out of these 21 studies, none of them showed any increased risk of recurring or development of aggressive prostate cancer with TRT.

One even determined a fourfold decrease in the risk of recurring prostate cancer in men undergoing low testosterone treatment therapy. All of these studies involved men who were prostate cancer patients and underwent testosterone replacement therapy.

The researchers concluded that their systematic review and meta-analysis of the studies did not show a higher rate of “biochemical recurrence” of prostate cancer with testosterone therapy administration. That is some positive and great news!

Why There May Be a Slight Possibility that TRT Could Increase Prostate Cancer Risk

According to Thierry Hertoghe, MD, there could still be a slight increase in prostate cancer risk, despite what the clinical studies are telling us. Dr. Hertoghe is the president of the International Hormone Society, specializing in hormone and anti-aging therapy.

His theory is that the risk of prostate cancer may increase if the testosterone in a man's body is converted to estradiol too frequently. Estradiol is considered more of a “female” hormone and has shown that it can cause metaplasia (transformation of cells into other cell types) of the epithelial cells comprising the prostate.

This would mainly be an issue for men whose body tends to convert too much testosterone into estradiol for whatever reason. High estrogen and estradiol levels can be measured in their blood and men who drink excessive alcohol and coffee can cause this phenomenon to happen.

In men with high conversion rates, TRT can still be administered, but an aromatase blocker should be prescribed as well. This aromatase blocker will block the action of the enzyme that converts testosterone to estradiol.

This makes TRT a little more tricky as you do not want to completely rid the body of estradiol but find a happy medium. This is simple to do if a patient follows their doctor's advice and administers the proper dosage of both the testosterone and the blocker.

Starting Testosterone Replacement Therapy

If you have been on the fence about starting a TRT program due to prostate cancer concerns, hopefully, the review of so many clinical studies by scientists has helped to ease your mind a bit.

As with any hormone therapy program, doing extensive research of your own before starting is a must. It is becoming increasingly apparent that the fears of developing prostate cancer can be lessened, especially if other methods can be utilized in conjunction with TRT, such as the use of an aromatase blocker.

If you are interested in TRT and want to learn more about your options regarding treatment, call one of our hormone advisors to discuss these as well as any safety concerns, free of charge. We are here to answer any questions you may have!


"21 Clinical Trials of Testosterone Therapy Given to Men With Prostate Cancer: The Results"

"Oncological Safety of Testosterone Replacement Therapy in Prostate Cancer Survivors After Definitive Local Therapy: A Systematic Literature Review and Meta-Analysis"

"Is Testosterone Therapy Good or Bad for the Heart? Or is it the Estradiol?"

Contact Us For HGH And Sermorelin Injection Treatment

Name (*)
Email (*)
Phone (*)
Select A Program (*)
Select US State (*)
Select Age (30+ only)

do hgh treatment work consultant over

Related Posts
red blood in test tube on white blank with results in colums
buy hgh chart injections.webp
hormone replacement therapy for hgh chart men.webp

List of USA state clinics - click a flag below for blood testing clinics.

alabama clinics
Alabama Hormone Blood Analysis
alaska clinics
Alaska Hormone Blood Analysis
arizona clinics
Arizona Hormone Blood Analysis
arkansas clinics
Arkansas Hormone Blood Analysis
california clinics
California Hormone Blood Analysis
colorado clinics
Colorado Hormone Blood Analysis
connecticut clinics
Connecticut Hormone Blood Analysis
delaware clinics
Delaware Hormone Blood Analysis
florida clinics
Florida Hormone Blood Analysis
georgia clinics
Georgia Hormone Blood Analysis
hawaii clinics
Hawaii Hormone Blood Analysis
idaho clinics
Idaho Hormone Blood Analysis
illinois clinics
Illinois Hormone Blood Analysis
indiana clinics
Indiana Hormone Blood Analysis
iowa clinics
Iowa Hormone Blood Analysis
kansas clinics
Kansas Hormone Blood Analysis
kentucky clinics
Kentucky Hormone Blood Analysis
louisiana clinics
Louisiana Hormone Blood Analysis
maine clinics
Maine Hormone Blood Analysis
maryland clinics
Maryland Hormone Blood Analysis
massachusetts clinics
Massachusetts Hormone Blood Analysis
michigan clinics
Michigan Hormone Blood Analysis
minnesota clinics
Minnesota Hormone Blood Analysis
mississippi clinics
Mississippi Hormone Blood Analysis
missouri clinics
Missouri Hormone Blood Analysis
montana clinics
Montana Hormone Blood Analysis
nebraska clinics
Nebraska Hormone Blood Analysis
nevada clinics
Nevada Hormone Blood Analysis
new hampshire clinics
New Hampshire Hormone Blood Analysis
new jersey clinics
New Jersey Hormone Blood Analysis
new mexico clinics
New Mexico Hormone Blood Analysis
new york clinics
New York Hormone Blood Analysis
north carolina clinics
North Carolina Hormone Blood Analysis
ohio clinics
Ohio Hormone Blood Analysis
oklahoma clinics
Oklahoma Hormone Blood Analysis
oregon clinics
Oregon Hormone Blood Analysis
pennsylvania clinics
Pennsylvania Hormone Blood Analysis
rhode island clinics
Rhode Island Hormone Blood Analysis
south carolina clinics
South Carolina Hormone Blood Analysis
south dakota clinics
South Dakota Hormone Blood Analysis
tennessee clinics
Tennessee Hormone Blood Analysis
texas clinics
Texas Hormone Blood Analysis
utah clinics
Utah Hormone Blood Analysis
vermont clinics
Vermont Hormone Blood Analysis
virginia clinics
Virginia Hormone Blood Analysis
washington clinics
Washington Hormone Blood Analysis
washington d.c clinics
Washington, D.C. Hormone Blood Analysis
west virginia clinics
West Virginia Hormone Blood Analysis
wisconsin clinics
Wisconsin Hormone Blood Analysis
wyoming clinics
Wyoming Hormone Blood Analysis

How useful was this post?

Click on a thumb to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this post.

Word Count: 848