What is the Molecular Structure of HGH?

Written by Dr. Jonathan Peterson, Updated on February 7th, 2024, Published on April 20th, 2023

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Human growth hormone (HGH) is a polypeptide hormone produced by the anterior pituitary gland. It is a single-chain molecule with 191 amino acids. The molecular weight of HGH is 22,124 daltons.

The amino acid sequence of HGH is highly conserved across species. The human HGH sequence is identical to that of other higher primates, such as chimpanzees and gorillas. The sequence is also similar to the sequences of HGH from other mammals, such as mice and rats.

The molecular structure of HGH has been determined by X-ray crystallography. The hormone is a globular protein with a tertiary structure that is stabilized by several disulfide bonds.

The hormone has two major domains, the N-terminal and the C-terminal domains. The N-terminal domain is responsible for binding HGH to its receptor, while the C-terminal domain is responsible for activating the receptor.

What dietary components contribute to the body's synthesis of HGH?

The body's synthesis of HGH is dependent on some dietary factors, including:

  • Amino acids: HGH is a protein, so the body must have an adequate supply of amino acids to synthesize it. The essential amino acids required for HGH synthesis are arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine.
  • Carbohydrates: Carbohydrates are the body's primary source of energy. They are also required for the synthesis of HGH. The hormone is synthesized in the liver, and the liver requires glucose to function correctly.
  • Fats: Fats are also required for the synthesis of HGH. They are a source of energy for the body, and they also provide the body with essential fatty acids needed for synthesizing hormones and other molecules.
  • Vitamins and minerals: Many vitamins and minerals are also required to synthesize HGH. These include:
    • Vitamin A
    • Vitamin B12
    • Vitamin D
    • Calcium
    • Magnesium
    • Zinc

Your body’s production of HGH

HGH is a complex hormone that is essential for several bodily functions. Its synthesis depends on many dietary factors, including amino acids, carbohydrates, fats, vitamins, and minerals.

By ensuring that you are getting enough of these nutrients in your diet, you can help ensure your body can produce adequate levels of HGH.

Some people, however, have a condition called adult-onset HGH deficiency. For them, the body does not produce enough HGH for good health, even if they are getting enough nutrients.

Are some adults unable to produce enough HGH, even if they are getting all the dietary nutrients needed to produce HGH?

Some factors can contribute to low HGH levels in adults, even if they get all the dietary nutrients needed to produce HGH. These factors include:

  • Age: HGH levels naturally decline with age. By 60, most adults have half the HGH levels they had in their 20s.
  • Genetics: Some people are genetically predisposed to low HGH levels.
  • Medical conditions: Several medical conditions can also lead to low HGH levels, including:
    • Chronic kidney disease
    • Chronic liver disease
    • HIV/AIDS
    • Thyroid disorders
    • Pituitary gland disorders
  • Medications: Some medications, such as steroids and certain antidepressants, can also lead to low HGH levels.
  • Lifestyle factors: Certain lifestyle factors, such as smoking, excessive alcohol consumption, and stress, can also contribute to low HGH levels. In some cases, adult-onset HGH deficiency occurs with no known cause.

If you are concerned that you may have low HGH levels, you should talk to the board-certified doctors at our clinic.

They can order a blood test to measure your HGH levels and determine if you are deficient. If you are found to be deficient in HGH, we are specialists in providing:

  • HGH replacement therapy: HGH replacement therapy is a treatment that involves injecting synthetic HGH into the body. This therapy can help to restore HGH levels to youthful levels. It can lead to a number of benefits, such as increased muscle mass, decreased body fat, increased energy levels, and improved sexual function.

If you are concerned about your HGH levels, talk to one of our physicians. We can help you determine if you have low HGH levels and recommend the best treatment option.

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