Vogelxo’s Impact on Nail and Skin Health in American Males: A 24-Month Study

Written by Dr. Jonathan Peterson, Updated on May 17th, 2025

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Introduction

Testosterone replacement therapy (TRT) has become increasingly prevalent among American males seeking to address hypogonadism and related symptoms. Vogelxo, a topical testosterone gel, is one such treatment that has gained popularity due to its ease of use and efficacy. However, the long-term effects of such treatments on dermatological health, particularly nail health and skin conditions, remain understudied. This article presents findings from a 24-month study examining the influence of Vogelxo on these aspects in American males.

Study Design and Methodology

The study involved 150 American males aged 30-65 diagnosed with hypogonadism and prescribed Vogelxo. Participants were monitored over 24 months, with regular assessments of their nail and skin health. Dermatological evaluations included visual inspections, dermatoscopic examinations, and patient-reported outcomes. The study aimed to identify any correlations between the use of Vogelxo and changes in dermatological conditions.

Effects on Nail Health

Throughout the study, participants' nail health was closely monitored. At the outset, baseline assessments showed a range of nail conditions, including onychomycosis, brittle nails, and nail discoloration. Over the 24 months, a notable improvement in nail strength and texture was observed in 68% of participants. This improvement was attributed to the increased testosterone levels, which are known to enhance keratin production, a vital component of nail structure.

However, 12% of participants reported an increase in nail fragility, which may be linked to the gel's alcohol content, known to dry out nails. Dermatologists recommended the use of moisturizing treatments to mitigate this side effect. Overall, the positive effects on nail health were significant, suggesting that Vogelxo can contribute to improved nail quality in many users.

Impact on Dermatological Conditions

The study also examined the impact of Vogelxo on various skin conditions. Acne, a common side effect of TRT, was reported in 25% of participants, primarily in the first six months of treatment. This was managed with topical treatments and subsided over time in most cases. Interestingly, 15% of participants noted an improvement in psoriasis symptoms, possibly due to the anti-inflammatory properties of testosterone.

Eczema was another condition monitored, with 10% of participants experiencing a flare-up during the study. This may be related to the skin's increased sensitivity to the gel's ingredients. Dermatologists advised using hypoallergenic moisturizers and avoiding irritants to manage these symptoms effectively.

Patient-Reported Outcomes

Patient-reported outcomes provided valuable insights into the subjective experience of using Vogelxo. Overall satisfaction with the treatment was high, with 85% of participants reporting improved energy levels and mood. However, 30% expressed concerns about skin irritation at the application site, which was addressed through adjustments in application techniques and the use of barrier creams.

Participants also noted changes in body hair growth, with 40% reporting increased hair density, particularly on the chest and face. While this was seen as a positive outcome by some, others found it challenging to manage and sought advice on hair removal methods.

Conclusion

The 24-month study on the impact of Vogelxo testosterone gel on dermatological health in American males revealed a complex interplay between testosterone supplementation and skin and nail conditions. While the majority of participants experienced improvements in nail strength and texture, some faced challenges with nail fragility and skin irritation. Acne and eczema were noted as potential side effects, though manageable with appropriate dermatological care.

These findings underscore the importance of regular monitoring and personalized treatment plans for individuals undergoing TRT. Dermatologists and healthcare providers should be aware of the potential dermatological effects of Vogelxo and provide guidance to ensure optimal outcomes for their patients. As TRT continues to gain popularity, further research is needed to fully understand its long-term effects on dermatological health.

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