Nicotinamide-N-methyltransferase (NNMT) Versus Its Inhibitor, a new way to promote weight loss?

Written by Dr. Jonathan Peterson, Updated on November 18th, 2020

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There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity, osteoarthritis, cardiovascular disease, cancer, Parkinson's disease, kidney disease, metabolic disorders, and other associated chronic metabolic co-morbidities.

Nicotinamide-N-methyltransferase (NNMT), is a cytosolic enzyme with newly identified cellular metabolism roles and energy homeostasis. Studies indicate that this enzyme slows down the process at which our bodies metabolize fat cells.

Most people have a hard time losing weight, and when these enzymes are elevated, they have a more challenging time trying to lose excess pounds of fat. The extra weight leads to an increase in the NNMT enzyme, leading to slower fat metabolism, leading to excess weight gain. It is a vicious cycle. 

Research suggests a potent NNMT inhibitor "5-amino-1mq" significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels. It also showed that you can increase muscle contraction force by 70%. 

These results support the development of small molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target to treat obesity and related metabolic conditions. 

This medication should not be taken longer than 30 days, and the optimal time to take it would be before a workout followed by your largest meal (of the day) right after. If you have any heart related conditions, you should not take this product. 

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