Striant Testosterone Buccal System’s Impact on Hearing in American Males: A 9-Month Study

Introduction

Testosterone replacement therapy (TRT) has become a widely utilized treatment for hypogonadism in men, with various delivery methods available, including the Striant testosterone buccal system. This system, which administers testosterone through a buccal tablet, has been the subject of interest due to its potential systemic effects. One area of concern is its impact on auditory function, as hormonal fluctuations can influence various physiological systems, including the auditory system. This article presents a longitudinal study examining the effects of the Striant testosterone buccal system on hearing in American males over a period of 9 months.

Study Design and Methodology

The study involved 100 American males aged between 30 and 65 years, all diagnosed with hypogonadism and prescribed the Striant testosterone buccal system. Participants underwent comprehensive audiological assessments at baseline, 3 months, 6 months, and 9 months. These assessments included pure-tone audiometry, speech audiometry, and otoacoustic emissions testing to evaluate hearing thresholds, speech understanding, and cochlear function, respectively.

Results: Hearing Thresholds

At baseline, the average hearing thresholds across all frequencies were within normal limits for the study population. Over the 9-month period, there was no statistically significant change in hearing thresholds at any frequency. This suggests that the Striant testosterone buccal system does not adversely affect hearing sensitivity in American males with hypogonadism.

Results: Speech Understanding

Speech audiometry results showed that participants maintained stable speech recognition scores throughout the study duration. The mean scores for speech understanding in quiet and noise conditions remained consistent, indicating that the buccal system did not impair speech perception abilities.

Results: Cochlear Function

Otoacoustic emissions testing, which provides insight into the function of the outer hair cells in the cochlea, revealed no significant changes over the 9 months. The presence and amplitude of otoacoustic emissions were stable, suggesting that the Striant testosterone buccal system does not negatively impact cochlear function.

Discussion

The findings of this study are reassuring for American males considering or currently using the Striant testosterone buccal system for TRT. The absence of significant changes in hearing thresholds, speech understanding, and cochlear function over the 9-month period indicates that this form of TRT is unlikely to have detrimental effects on auditory function.

It is important to consider these results in the context of the study's limitations. The sample size, while sufficient for detecting significant changes, may not capture rare or subtle effects. Additionally, the study duration of 9 months may not be long enough to observe long-term effects on hearing. Future research should include larger cohorts and longer follow-up periods to further validate these findings.

Clinical Implications

For clinicians prescribing the Striant testosterone buccal system, these results suggest that routine audiological monitoring may not be necessary solely due to the use of this TRT method. However, patients with pre-existing hearing issues or those at higher risk for hearing loss should continue to receive regular audiological evaluations as part of their overall health management.

Conclusion

This longitudinal study provides evidence that the Striant testosterone buccal system does not adversely affect hearing in American males with hypogonadism over a 9-month period. These findings contribute to the growing body of knowledge on the safety profile of TRT and can help guide clinical decision-making for both patients and healthcare providers. As with any medical treatment, ongoing research and patient monitoring are essential to ensure the continued safety and efficacy of testosterone replacement therapies.

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