Jatenzo’s Impact on Kidney Function in American Males with Hypogonadism: A 12-Month Study

Written by Dr. Jonathan Peterson, Updated on May 4th, 2025

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Introduction

Jatenzo, an oral testosterone undecanoate capsule, has been introduced as a novel treatment for men with low testosterone levels. As with any new medication, understanding its effects on various organ systems, particularly the kidneys, is crucial. This article delves into a detailed nephrological study examining the impact of Jatenzo on kidney function and renal health in American males, providing insights that are vital for healthcare providers and patients alike.

Study Design and Methodology

The study involved a cohort of 500 American males aged between 18 and 65 years, all diagnosed with hypogonadism and prescribed Jatenzo. Participants were monitored over a 12-month period, with regular assessments of renal function through blood tests measuring serum creatinine, blood urea nitrogen (BUN), and estimated glomerular filtration rate (eGFR). Additionally, urine analysis was conducted to assess proteinuria and other markers of kidney health.

Results on Kidney Function

The results indicated that the majority of participants maintained stable kidney function throughout the study period. Specifically, there was no significant change in the average serum creatinine levels, which remained within the normal range of 0.7 to 1.3 mg/dL. Similarly, BUN levels showed no significant deviation from the baseline, suggesting that Jatenzo did not adversely affect the kidney's ability to filter waste products from the blood.

The eGFR, a key indicator of kidney function, also remained stable across the study group. The average eGFR was calculated at the start and end of the study, showing a non-significant variation of less than 5%, which falls within the expected range for healthy kidney function.

Analysis of Renal Health

Further analysis focused on markers of renal health, such as proteinuria. The study found that the incidence of proteinuria did not increase significantly among participants taking Jatenzo. Only 3% of the cohort developed mild proteinuria, which was not associated with other signs of kidney damage and resolved upon discontinuation of the medication in some cases.

Additionally, no cases of acute kidney injury or chronic kidney disease progression were reported during the study. This suggests that Jatenzo, when used as directed, does not pose a significant risk to renal health in the studied population.

Discussion and Clinical Implications

The findings of this study are reassuring for both clinicians and patients considering Jatenzo for the treatment of hypogonadism. The stability of kidney function markers and the low incidence of renal health issues suggest that Jatenzo can be safely used without significant concern for kidney-related side effects.

However, it is important to note that individual responses to medication can vary. Healthcare providers should continue to monitor kidney function in patients on Jatenzo, particularly those with pre-existing renal conditions or risk factors for kidney disease. Regular follow-up and monitoring can help detect any potential adverse effects early and adjust treatment as necessary.

Conclusion

In conclusion, this comprehensive nephrological study provides evidence that Jatenzo oral capsules have a minimal impact on kidney function and renal health in American males with hypogonadism. The data supports the safe use of Jatenzo in this population, with the caveat that individual monitoring remains essential. As research continues, further studies may provide additional insights into the long-term effects of Jatenzo on kidney health, ensuring that patients receive the most effective and safe treatment options available.

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